Dr. Saperstein has cared for over 2,500 patients with EDS, POTS and related conditions. This has allowed him and his team to attain key knowledge and skills necessary to diagnose and manage patients with these disorders. There can be many other conditions that complicate the clinical picture, to include mast cell activation syndrome (MCAS), craniocervical instability (CCI), spinal fluid leaks, migraines, small fiber neuropathy, autoimmune disorders, as well as inflammatory and infectious diseases.